College football picks for Week 13: Big Ten, SEC showdowns lead Top 25 schedule

USA Today
Original Story by USA Today
November 20, 2025
College football picks for Week 13: Big Ten, SEC showdowns lead Top 25 schedule

Week 13 of college football features significant matchups, particularly in the Big Ten and SEC, with No. 5 Oregon hosting No. 16 Southern California and No. 8 Oklahoma facing No. 21 Missouri. These games, among others, highlight the competitive landscape as teams aim to secure their standings in the US LBM Coaches Poll Top 25. While there are some less challenging contests, the weekend promises to provide opportunities for both established and emerging teams to prove themselves. The outcomes of these games could have implications for playoff positioning as the season progresses. Expert predictions will be shared to gauge potential performance in these pivotal matchups.

Dive Deeper:

  • No. 5 Oregon is set to host No. 16 Southern California in a key Big Ten matchup, which is expected to draw significant attention due to both teams' rankings and performance this season.

  • In the SEC, No. 8 Oklahoma will take on No. 21 Missouri, marking a crucial game for both teams as they look to improve their standings and secure bowl game eligibility.

  • No. 13 Vanderbilt will face Kentucky, who has shown improvement recently, making this game vital for both teams in their respective conference races.

  • In the Big 12, No. 12 Brigham Young will travel to play Cincinnati, adding to the weekend's lineup of games that could impact playoff considerations.

  • The ACC features a matchup between No. 16 Georgia Tech and Pittsburgh, further emphasizing the weekend's competitive slate among ranked teams.

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