He made it to the other side of Stage 4 colorectal cancer. How?
Philip Felshman, diagnosed with Stage IV colorectal cancer in January 2025, faced a dire prognosis as the disease had metastasized to his liver and lungs. However, after undergoing a novel treatment called hepatic artery infusion (HAI), which delivers high-dose chemotherapy directly to the liver, Felshman achieved remarkable results, with significant tumor reduction and is now cancer-free. This treatment is not universally applicable and requires careful patient selection and monitoring, emphasizing the importance of timely referrals to specialized centers. As HAI gains traction as a growing cancer care paradigm, awareness and early detection remain crucial for improving outcomes in colorectal cancer patients.
Dive Deeper:
Felshman experienced alarming symptoms before his diagnosis, struggling to walk up stairs, which led to the discovery of his condition. His prognosis initially indicated only a few years to live.
The hepatic artery infusion (HAI) pump was a critical part of Felshman's treatment, enabling higher concentrations of chemotherapy directly to the liver, which is crucial for targeting metastasized tumors.
Dr. Nicholas Hornstein, Felshman's oncologist, noted that only 10% to 15% of colorectal cancer patients are suitable for HAI treatment, highlighting a significant treatment gap in oncology.
Despite the success of HAI, it is not suitable for all patients, particularly those with extensive prior chemotherapy or those whose cancer has spread beyond the liver.
Complications from HAI can include pump malfunctions and potential liver damage from the intense chemotherapy doses, necessitating a highly experienced medical team for safe administration.
Felshman urges others to prioritize early screenings and to advocate for their health by asking questions and seeking second opinions if they do not feel comfortable with treatment plans.
The challenge remains for medical centers to expand HAI availability due to the specialized skills required, though its recognition as a treatment option is increasing.